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1

The inhibitory effect of alcide®, an antimicrobial drug, on protein synthesis in Escherichia coli

Joann Scatina, Mohamed S. Abdel-Rahman, Emanuel Goldman

Journal:

Journal of Applied Toxicology

Year:

1985

Language:

english

File:

PDF, 657 KB

english, 1985

2

Quantitation of cytochrome P450 mRNA levels in human skin

Lilian G Yengi, Qian Xiang, Jinmei Pan, JoAnn Scatina, John Kao, Simon E Ball, Richard Fruncillo, Geraldine Ferron, C Roland Wolf

Journal:

Analytical Biochemistry

Year:

2003

Language:

english

File:

PDF, 112 KB

english, 2003

3

Bazedoxifene Acetate Metabolic Disposition in Healthy, Postmenopausal Women

Chandrasckaran, A., Ermer, J., McKeand, W., Lee, H., DeMaio, W., Kotake, A., Sullivan, P., Orczyk, G., Scatina, J.

Journal:

Clinical Pharmacology & Therapeutics

Year:

2003

Language:

english

File:

PDF, 131 KB

english, 2003

4

Venlafaxine: in vitro inhibition of CYP2D6 dependent imipramine and desipramine metabolism; comparative studies with selected SSRIs, and effects on human hepatic CYP3A4, CYP2C9 and CYP1A2

Simon E. Ball, Dennis Ahern, Joann Scatina, John Kao

Journal:

British Journal of Clinical Pharmacology

Year:

1997

Language:

english

File:

PDF, 386 KB

english, 1997

5

Pharmacokinetics of venlafaxine and O -desmethylvenlafaxine in laboratory animals

Howell, S. R., Hicks, D. R., Scatina, J. A., Sisenwine, S. F.

Journal:

Year:

1994

Language:

english

File:

PDF, 656 KB

english, 1994

6

Metabolism of Vabicaserin in Mice, Rats, Dogs, Monkeys, and Humans

Tong, Z., Chandrasekaran, A., DeMaio, W., Espina, R., Lu, W., Jordan, R., Scatina, J.

Journal:

Drug Metabolism and Disposition

Year:

2010

Language:

english

File:

PDF, 2.18 MB

english, 2010

7

Metabolic Disposition of [14C]Bazedoxifene in Healthy Postmenopausal Women

Chandrasekaran, A., McKeand, W. E., Sullivan, P., DeMaio, W., Stoltz, R., Scatina, J.

Journal:

Drug Metabolism and Disposition

Year:

2009

Language:

english

File:

PDF, 293 KB

english, 2009

8

Species differences in the pharmacokinetics of recainam, a new anti-arrhythmic drug

J. A. Scatina, H. B. Kimmel, V. Weinstein, S. M. Troy, S. F. Sisenwine, M. N. Cayen

Journal:

Biopharmaceutics & Drug Disposition

Year:

1990

Language:

english

File:

PDF, 774 KB

english, 1990

9

The disposition of venlafaxine enantiomers in dogs, rats, and humans receiving venlafaxine

C. Paul Wang, Stanley R. Howell, Joann Scatina, Samuel F. Sisenwine

Journal:

Year:

1992

Language:

english

File:

PDF, 643 KB

english, 1992

10

A reporter gene cellular model for evaluating induction of CYP3A4 by new chemical entities

Julius Enoru-Eta, Lilian G. Yengi, John Kao, JoAnn Scatina

Journal:

Drug Development Research

Year:

2006

Language:

english

File:

PDF, 141 KB

english, 2006

11

Pharmacokinetics of Alcide®, a germicidal compound in rat

Joann Scatina, Mohamed S. Abdel-Rahman, Samy E. Gerges, Howard Alliger

Journal:

Journal of Applied Toxicology

Year:

1983

Language:

english

File:

PDF, 334 KB

english, 1983

12

The effect of alcide®, a new antimicrobial drug, on rat blood glutathione and erythrocyte osmotic fragility, in vitro

Mohamed S. Abdel-Rahman, Joann Scatina

Journal:

Journal of Applied Toxicology

Year:

1985

Language:

english

File:

PDF, 337 KB

english, 1985

13

Characterization of metabolites of Δ8,9-dehydroestrone in dogs

A. Chandrasekaran, M. Osman, P. Raveendranath, K. Chan, J. A. Scatina, S. F. Sisenwine

Journal:

Journal of Mass Spectrometry

Year:

1995

Language:

english

File:

PDF, 527 KB

english, 1995

14

Determination of 17α-dihydroequilenin in rat, rabbit and monkey plasma by high-performance liquid chromatography with fluorimetric detection

Appavu Chandrasekaran, Mohamed Osman, Steven J. Adelman, Joseph Warsheski, JoAnn Scatina, Samuel F. Sisenwine

Journal:

Journal of Chromatography B: Biomedical Sciences and Applications

Year:

1996

Language:

english

File:

PDF, 461 KB

english, 1996

15

Population distribution and effects on drug metabolism of a genetic variant in the 5′ promotor region of CYP3A4

Ball, Simon E., Scatina, JoAnn, Kao, John, Ferron, Geraldine M., Fruncillo, Richard, Mayer, Philip, Weinryb, Ira, Guida, Marco, Hopkins, Penelope J., Warner, Natalie, Hall, Jeff

Journal:

Clinical Pharmacology & Therapeutics

Year:

1999

Language:

english

File:

PDF, 80 KB

english, 1999

16

Etodolac kinetics in the elderly

Scatina, JoAnn, Hicks, David, Kraml, Michael, Weidler, Donald, Garg, Dyal, Sanda, Marie

Journal:

Clinical Pharmacology & Therapeutics

Year:

1986

Language:

english

File:

PDF, 326 KB

english, 1986

17

Venlafaxine (VF): Effects on CYP2D6 dependent imipramine (IMP) and desipramine (DMP) 2-hydroxylation; Comparative studies with fluoxetine (FLU) and effects on CYP1A2, CYP3A4 and CYP2C9.

Ball, S., Ahern, D., Kao, J., Scatina, J.

Journal:

Clinical Pharmacology & Therapeutics

Year:

1996

Language:

english

File:

PDF, 147 KB

english, 1996

18

Alternate Strategies to Obtain Mass Balance without the Use of Radiolabeled Compounds: Application of Quantitative Fluorine (19F) Nuclear Magnetic Resonance (NMR) Spectroscopy in Metabolism Studies

Mutlib, Abdul, Espina, Robert, Atherton, James, Wang, Jianyao, Talaat, Rasmy, Scatina, JoAnn, Chandrasekaran, Appavu

Journal:

Chemical Research in Toxicology

Year:

2012

Language:

english

File:

PDF, 723 KB

english, 2012

19

Metabolic disposition of 14 C-venlafaxine in mouse, rat, dog, rhesus monkey and man

Howell, S. R., Husbands, G. E. M., Scatina, J. A., Sisenwine, S. F.

Journal:

Year:

1993

Language:

english

File:

PDF, 746 KB

english, 1993

20

Fibroblasts transformed by an oncogenic virus show decreased uptake of puromycin aminonucleoside

George P. Studzinski, Ernest A. Albanese, Joann Scatina, Marsha Trocola-Simchera

Journal:

Biochemical and Biophysical Research Communications

Year:

1980

Language:

english

File:

PDF, 264 KB

english, 1980

21

Inhibition of zaleplon metabolism by cimetidine in the human liver: in vitro studies with subcellular fractions and precision-cut liver slices

Renwick, A. B., Ball, S. E., Tredger, J. M., Price, R. J., Walters, D. G., Kao, J., Scatina, J. A., Lake, B. G.

Journal:

Year:

2002

Language:

english

File:

PDF, 351 KB

english, 2002

22

A High Performance Liquid Chromatographic Method for the Determination of Rapamycin (Sirolimus) in Rat Serum, Plasma, and Blood and in Monkey Serum

Wang, C. Paul, Scatina, Joann, Sisenwine, Samuel F.

Journal:

Journal of Liquid Chromatography

Year:

1995

Language:

english

File:

PDF, 290 KB

english, 1995

23

Pharmacodynamics of Alcide, a new antimicrobial compound, in rat and rabbit*1

Journal:

Fundamental and Applied Toxicology

Year:

1984

Language:

english

File:

PDF, 486 KB

english, 1984

24

Metabolism of equilin sulfate in the dog

Chandrasekaran, A., Osman, M., Scatina, J.A., Sisenwine, S.F.

Journal:

The Journal of Steroid Biochemistry and Molecular Biology

Year:

1995

Language:

english

File:

PDF, 665 KB

english, 1995

25

Obtaining Exposures of Metabolites in Preclinical Species through Plasma Pooling and Quantitative NMR: Addressing Metabolites in Safety Testing (MIST) Guidance without Using Radiolabeled Compounds and Chemically Synthesized Metabolite Standards

Vishwanathan, Karthick, Babalola, Kathlene, Wang, Jack, Espina, Robert, Yu, Linning, Adedoyin, Adedayo, Talaat, Rasmy, Mutlib, Abdul, Scatina, JoAnn

Journal:

Chemical Research in Toxicology

Year:

2009

Language:

english

File:

PDF, 1.35 MB

english, 2009

26

Nuclear Magnetic Resonance Spectroscopy as a Quantitative Tool To Determine the Concentrations of Biologically Produced Metabolites: Implications in Metabolites in Safety Testing

Espina, Robert, Yu, Linning, Wang, Jianyao, Tong, Zeen, Vashishtha, Sarvesh, Talaat, Rasmy, Scatina, JoAnn, Mutlib, Abdul

Journal:

Chemical Research in Toxicology

Year:

2009

Language:

english

File:

PDF, 358 KB

english, 2009

27

A Novel Approach for Predicting Acyl Glucuronide Reactivity via Schiff Base Formation: Development of Rapidly Formed Peptide Adducts for LC/MS/MS Measurements

Wang, Jianyao, Davis, Margaret, Li, Fangbiao, Azam, Farooq, Scatina, JoAnn, Talaat, Rasmy

Journal:

Chemical Research in Toxicology

Year:

2004

Language:

english

File:

PDF, 208 KB

english, 2004

28

Simultaneous Screen for Microsomal Stability and Metabolite Profile by Direct Injection Turbulent-Laminar Flow LC−LC and Automated Tandem Mass Spectrometry

Lim, H. K., Chan, K. W., Sisenwine, S., Scatina, J. A.

Journal:

Analytical Chemistry

Year:

2001

Language:

english

File:

PDF, 104 KB

english, 2001

29

Disposition of bazedoxifene in rats

Chandrasekaran, A., Ahmad, S., Shen, L., DeMaio, W., Hultin, T., Scatina, J.

Journal:

Year:

2010

Language:

english

File:

PDF, 718 KB

english, 2010

30

High Performance Liquid Chromatographic Isolation, Spectroscopic Characterization, and Immunosuppressive Activities of Two Rapamycin Degradation Products

Wang, C. Paul, Chan, Kelvin W., Schiksnis, Robert A., Scatina, Joann, Sisenwine, Samuel F.

Journal:

Journal of Liquid Chromatography

Year:

1994

Language:

english

File:

PDF, 361 KB

english, 1994

31

Drug Metabolism Handbook || The Role of Drug Metabolism in Toxicity

Nassar, Ala F., Hollenberg, Paul F., Scatina, JoAnn

Year:

2009

Language:

english

File:

PDF, 883 KB

english, 2009

32

Application of Quantitative NMR in Pharmacological Evaluation of Biologically Generated Metabolites: Implications in Drug Discovery

Mutlib, A., Espina, R., Vishwanathan, K., Babalola, K., Chen, Z., Dehnhardt, C., Venkatesan, A., Mansour, T., Chaudhary, I., Talaat, R., Scatina, J.

Journal:

Drug Metabolism and Disposition

Year:

2011

Language:

english

File:

PDF, 1.26 MB

english, 2011

33

Metabolism of zaleplon by human liver: evidence for involvement of aldehyde oxidase

Lake, B. G., Ball, S. E., Kao, J., Renwick, A. B., Price, R. J., Scatina, J. A.

Journal:

Year:

2002

Language:

english

File:

PDF, 317 KB

english, 2002

34

Drug Metabolism Handbook || Automated Drug Screening for ADMET Properties

Nassar, Ala F., Hollenberg, Paul F., Scatina, JoAnn

Year:

2009

Language:

english

File:

PDF, 5.69 MB

english, 2009

35

Drug Metabolism Handbook || Drug Metabolism in Regulatory Guidances, Clinical Trials, and Product Labeling

Nassar, Ala F., Hollenberg, Paul F., Scatina, JoAnn

Year:

2009

Language:

english

File:

PDF, 1.08 MB

english, 2009

36

Drug Metabolism Handbook || An Introduction to Metabolic Reaction Phenotyping

Nassar, Ala F., Hollenberg, Paul F., Scatina, JoAnn

Year:

2009

Language:

english

File:

PDF, 995 KB

english, 2009

37

Drug Metabolism Handbook || Mechanisms of Reproductive Toxicity

Nassar, Ala F., Hollenberg, Paul F., Scatina, JoAnn

Year:

2009

Language:

english

File:

PDF, 1.07 MB

english, 2009

38

In Vitro Metabolism, Permeability, and Efflux of Bazedoxifene in Humans

Shen, L., Ahmad, S., Park, S., DeMaio, W., Oganesian, A., Hultin, T., Scatina, J., Bungay, P., Chandrasekaran, A.

Journal:

Drug Metabolism and Disposition

Year:

2010

Language:

english

File:

PDF, 884 KB

english, 2010

39

Characterization of HKI-272 Covalent Binding to Human Serum Albumin

Wang, J., Li-Chan, X. X., Atherton, J., Deng, L., Espina, R., Yu, L., Horwatt, P., Ross, S., Lockhead, S., Ahmad, S., Chandrasekaran, A., Oganesian, A., Scatina, J., Mutlib, A., Talaat, R.

Journal:

Drug Metabolism and Disposition

Year:

2010

Language:

english

File:

PDF, 1.16 MB

english, 2010

40

High Performance Liquid Chromatographic Isolation and Spectroscopic Characterization of Three Major Metabolites from the Plasma of Rats Receiving Rapamycin (Sirolimus) Orally

Wang, C. Paul, Lim, Heng-Keang, Chan, Kelvin W., Scatina, Joann, Sisenwine, Samuel F.

Journal:

Journal of Liquid Chromatography

Year:

1995

Language:

english

File:

PDF, 366 KB

english, 1995

41

Metabolism, Excretion, and Pharmacokinetics of [14C]Tigecycline, a First-In-Class Glycylcycline Antibiotic, after Intravenous Infusion to Healthy Male Subjects

Hoffmann, M., DeMaio, W., Jordan, R. A., Talaat, R., Harper, D., Speth, J., Scatina, J.

Journal:

Drug Metabolism and Disposition

Year:

2007

Language:

english

File:

PDF, 462 KB

english, 2007

42

Metabolism of Intravenous Methylnaltrexone in Mice, Rats, Dogs, and Humans

Chandrasekaran, A., Tong, Z., Li, H., Erve, J. C. L., DeMaio, W., Goljer, I., McConnell, O., Rotshteyn, Y., Hultin, T., Talaat, R., Scatina, J.

Journal:

Drug Metabolism and Disposition

Year:

2010

Language:

english

File:

PDF, 2.26 MB

english, 2010

43

Use of a quantitative real-time reverse transcription-polymerase chain reaction method to study the induction of CYP1A, CYP2B and CYP4A forms in precision-cut rat liver slices

Pan, J., Xiang, Q., Renwick, A. B., Price, R. J., Ball, S. E., Kao, J., Scatina, J. A., Lake, B. G.

Journal:

Year:

2002

Language:

english

File:

PDF, 280 KB

english, 2002

44

In Vitro Metabolism and Identification of Human Enzymes Involved in the Metabolism of Methylnaltrexone

Tong, Z., Chandrasekaran, A., Li, H., Rotshteyn, Y., Erve, J. C. L., DeMaio, W., Talaat, R., Hultin, T., Scatina, J.

Journal:

Drug Metabolism and Disposition

Year:

2010

Language:

english

File:

PDF, 801 KB

english, 2010

45

Mechanism Study of N-Dephenylation Mediated through a N-para-Hydroxy Metabolite

Wang, Jianyao, DeMaio, William, Chandrasekaran, Appavu, Shen, Li, Bach II, Alvin, Scatina, JoAnn, Talaat, Rasmy

Journal:

Current Drug Discovery Technologies

Year:

2006

Language:

english

File:

PDF, 427 KB

english, 2006

46

Effects of ertiprotafib on hepatic cytochrome P450 and peroxisomal enzymes in rats and dogs, and in rat and human primary hepatocytes

Tong, Z., Chandrasekaran, A., Jordan, R., Markiewicz, V., Li, H., Xiang, Q., Shen, L., Scatina, J.

Journal:

Year:

2007

Language:

english

File:

PDF, 130 KB

english, 2007

47

Pharmacodynamics of Alcide, a New Antimicrobial Compound, in Rat and Rabbit

SCATINA, JOANN, ABDEL-RAHMAN, MOHAMED S., GERGES, SAMY E., KHAN, M. YASUF, GONA, OPHELIA

Journal:

Toxicological Sciences

Year:

1984

Language:

english

File:

PDF, 374 KB

english, 1984

48

Application of Pharmacogenomics in Drug Discovery and Development:Correlations Between Transcriptional Modulation and Preclinical Safety Observations

Yengi, Lilian, Xiang, Qian, Shen, Li, Chandrasekaran, Appavu, Kao, John, Scatina, JoAnn

Journal:

Drug Metabolism Letters

Year:

2007

Language:

english

File:

PDF, 262 KB

english, 2007

49

Reversible Covalent Binding of Neratinib to Human Serum Albumin In Vitro

Chandrasekaran, Appavu, Shen, Li, Lockhead, Susan, Oganesian, Aram, Wang, Jianyao, Scatina, JoAnn

Journal:

Drug Metabolism Letters

Year:

2010

Language:

english

File:

PDF, 484 KB

english, 2010

50

Development of a UGT1A1 Reporter Gene Assay for Induction Studies: Correlation Between Reporter Gene Data and Regulation of UGT1A1 in Human Hepatocytes

Enoru-Eta, Julius, Yengi, Lilian, He, Xiaoyang, Kubik, Joseph, Kao, John, Scatina, Joann

Journal:

Drug Metabolism Letters

Year:

2010

Language:

english

File:

PDF, 778 KB

english, 2010

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